Probiotic Supplementation as a Mitigator of High-Sugar Diet Effects

Abstract

High-sugar diets are associated with a multitude of adverse health outcomes, including metabolic disorders, chronic inflammation, gut microbiota imbalance, and compromised immune function. This study explores the efficacy of probiotic supplementation in mitigating these effects through the restoration of gut microbiota and modulation of systemic inflammation. Employing a controlled animal experiment over an eight-week period, we evaluated metabolic parameters, inflammatory markers, gut microbiota composition, and histological changes across four groups: control, high-sugar diet (HSD), HSD with probiotic supplementation, and probiotics alone. The findings indicate that probiotic supplementation significantly attenuates weight gain, insulin resistance, systemic inflammation, and microbial dysbiosis induced by high-sugar consumption. The study highlights the potential of targeted microbiome modulation via probiotics as a therapeutic adjunct to dietary management in combating diet-induced metabolic disturbances.